Zinc Gluconate is the active ingredient in Cold-EEZE®. The proprietary formula starts working immediately to release zinc ions in the mouth. The release of zinc ions inhibits the cold virus's ability to replicate, shortening the duration of the common cold.* A clinical study found the Cold-EEZE Zinc Lozenge formula reduces the duration of the common cold by 42%, when taken at the first sign of a cold and used as directed. The double blind placebo controlled study was conducted at the Cleveland Clinic and published in a peer reviewed journal.

*Although the precise mechanism by which zinc ions affect the cold virus has not been scientifically established, the Cleveland Clinic study found that Cold-EEZE lozenges reduced the duration of the common cold.